Swiss Chinese Herbal Medicine and Functional Food Innovation Center

Sergey Girel Chemist, M. Sc. Analytical chemistry / Mass spectrometry born 21.06.1986 in Novorossiysk, RUS	Current affiliation: University of Geneva / PhD student Section des science pharmaceutiques Group of Prof. Dr. Serge Rudaz sergey.girel@unige.ch
Research interests:         High resolution mass spectrometry for complex workflows in metabolomics         Hyphenation techniques for broad metabolite coverage Chromatography: miniaturized and ballistic separations         Data treatment and rational design of experiments (DoE), annotation methodology         Applications of metabolomics in health and disease
Key skills: analytical development, LC/HRMS (FT, ICR, QToF), 1D/2D NMR, optical spectroscopy, metabolomics, complex structure elucidation, metabolite isolation and characterization, R Experience: metabolomic pipeline development, metabolic profiling, determination, isolation and quantification of active principles, de novo structure elucidation of metabolites, identification of metabolic cross-kingdom interactions Languages: Russian (Native), English (C1), German (C1) + Swiss dialect
Academic qualifications: 2019 University of Zürich, M. Sc. Chemistry – Analytical chemistry / Complex structure elucidation (Switzerland) 2018 University of Zürich, B. Sc. Chemistry and Business studies (Switzerland) 2010 Medical College of the City of Novorossiysk – Pharmacy (Russia)
Work experience: 2020 Federal competence center for agricultural research “Agroscope” (Switzerland) – LC/MS specialist 2019 Federal institute for sustainable agriculture (FiBL, Switzerland) – Research consultant 2018 University of Zürich (Switzerland) – Teaching assistant (Spectroscopy, BA level)

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Comprehensive steroid profiling in patients with different stages of prostate cancer disease

Girel S., Markin P., Moskaleva N., Tobolkina E., Rudaz S., Appolonova S.

In preparation

Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid

Olesti E., Boccard J., Rahban R., Girel S., Moskaleva N. E., Zufferey F., Rossier M. F., Nef S., Rudaz S., González-Ruiz V.

Submitted

Investigation of several chromatographic approaches for untargeted profiling of central carbon metabolism

Girel. S, Guillarme D., Fekete S., Rudaz S., González-Ruiz V., Journal of Chromatography A, 463994 (2023)

(10.1016/j.chroma.2023.463994)

Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in St. aureus.

Manna, A.C., Leo, S., Girel, S. et al.  Sci Rep 12, 14963 (2022) (10.1038/s41598-022-18815-3)

Bioactive Nitrosylated and Nitrated N-(2-hydroxyphenyl) acetamides and Derived Oligomers: An Alternative Pathway to 2-Amidophenol-Derived Phytotoxic Metabolites.

Girel, S., Schütz, V., Bigler, L., Dörmann, P., Schulz, M. Molecules, 27, 4786 (2022) (10.3390/molecules27154786)

Separation and determination of cysteine enantiomers in plasma after derivatization with 4-fluoro-7-nitrobenzofurazan.

Ferré S., González-Ruiz V., Zangari J., Girel S., Martinou JC., Sardella R., Rudaz S. JPBA, 209, 114539 (2022) (10.1016/j.jpba.2021.114539)

Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin.

Guan, P., Zhou, J., Girel, S., Zhu, X., Schwab, M., Zhang, K., Wang-Müller, Q., Bigler, L., and Nick, P.

J. Integr. Plant Biol., 63, 2058 (2021) (10.1111/jipb.13177)

Conversions of Benzoxazinoids and Downstream Metabolites by Soil Microorganisms.

Schütz V., Bigler L., Girel S., Laschke L., Sicker D., Schulz M. Front. Ecol. Evol., 7 (2019) (10.3389/fevo.2019.00238)